Fox’s medical drama Doc, starring Emmy nominee Molly Parker (House of Cards), returns for season two on September 23, 2025 at 9pm ET/PT. The network just released the first trailer for the upcoming season, which will find Amy still trying to piece together parts of her life prior to her horrible accident.
In addition to Parker, season two stars Omar Metwally as Dr. Michael Hamda, Felicity Huffman as Dr. Joan Ridley, Amirah Vann as Dr. Gina Walker, and Charlotte Fountain-Jardim as Katie Hamda. Jon Ecker plays Dr. Jake Heller and Anya Banerjee plays Dr. Sonya Maitra.
Barbie Kligman and Hank Steinberg guide season two as showrunners and executive producers. Additional executive producers include Erwin Stoff and Judith McCreary. The series is co-produced by Sony Pictures Television and FOX Entertainment Studios.
Fox released the following description of the popular medical drama:
“Inspired by a true story and based on the hit eponymous Italian drama series, Doc begins its second season of the life-affirming medical drama following the heartbreak and victories of hard-charging, brilliant physician DR. AMY LARSEN (Parker) as she rebuilds her life after a car crash erased eight years of her memory. This season, Amy will continue to confront hard truths about her missing years, work to repair fractured relationships and seek to reconcile the person she used to be with the one everyone else has come to know.
Determined to get her memory back and piece together who she really is, Amy’s goal is to become the doctor she used to be in those missing years and to eventually, once again, be Chief of Internal Medicine. In the interim, her ex-husband/Westside Hospital’s Chief Medical Officer, DR. MICHAEL HAMDA (Metwally) fills the position with Amy’s former mentor and friend DR. JOAN RIDLEY (Huffman), whose motives and priorities remain hidden, just as long as Amy still can’t recall Joan’s life-changing secret. Amy’s best friend and colleague, DR. GINA WALKER (Vann), is weary of Joan’s motives and continues to be a beacon of support for those around her, while finally learning to put on her own oxygen mask first.
While relearning eight years of medical advancements is complicated, it pales in comparison to learning to navigate her new/old/current romantic entanglements. Amy continues to fight her feelings and let Michael go, especially now with the birth of his son with his new wife, bringing up emotions for both Amy and their daughter KATIE HAMDA (Fountain-Jardim). Amy’s on-again, off-again relationship with Chief Resident DR. JAKE HELLER (Ecker) is a bit more delicate as he struggles to protect his heart from her this time around. However, DR. SONYA MAITRA (Banerjee) would only be too glad to pick up the pieces, navigating the balance between her feelings for Jake and her complicated resentment towards Amy.
The second season of Doc begins as Amy’s past comes back to haunt her when a desperate father sacrifices everything to secure his daughter’s heart transplant. Chaos and confusion reverberate through the hallways of Westside Medical when a subsequent high-stakes emergency leaves a doctor’s life in the balance.”
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